General items but not always,
Skoolie; less expensive, truck frame which allows for more "house" changing such as slide outs and roof raise, more available, harsher ride, shorter wheel base, tighter turn radius, less under storage, easier access to work on engine- if front engine, less welcome in camp grounds, usually built for in town driving so gearing and engine are sufficient but can be less desirable for highway, truck frame allows more towing capacity
Couch; more expensive, most are air bag suspension so smoother ride, longer wheel base, wider turn radius, several kinds of body structure but most are reliant on outer skin like an airplane so less options for body mods or at least harder, more under storage, easier to make look like an rv so a bit more welcome in parks, some are built city, a lot built for highway, engine and gearing can be more desirable for highway, no real frame makes it tricky to tow larger loads
I'm sure there are more, and again these are General statements, there are exceptions to all of the above, more on some and less on others.
Please chime in and correct me and add to the list