To answer your question they all work the same home or car. What it depends on is how much resistance each speaker has? It should be marked on the speaker itself. Typically home speakers are 8 ohms and cars are 4 ohms. Some of the newer sub woofers are lower in impeadance.
Your stereo (or amp) will be rated for some much power at some many ohms. For example my head unit in my truck is a JVC is rated MOS-FET 50W x 4 (20W RMS x 4) is what it can output. You can add more speakers but you take the risk of burning up the amp in the tuner.
Here is a website that may help? http://www.bcae1.com/spkrmlti.htm
Probably best bet if you are not use to calculating those things is one speaker per channel. You can also take them to a stereo shop and that can help you out in a hands on aspect?
Hope that helps