In addition to the fuel level sender, it looks like your fuel supply and return hoses are also accessible through this access hole. If you end up with a clogged tank screen (if so equipped) or a hose gets old and goes bad, or any number of other tank access scenarios, you will be glad you left that access hole accessible. Check out the size of the tank mounting framework, not to mention the size and weight of the tank itself!
You do NOT want to be forced to remove and reinstall that thing!