11 windows should be plenty of space for what you want to do. Check out my build thread, starting here or so,
I guess. I'm really only using 10 windows of space (about 24' long) but I have room for a cot along with washer and dryer (all in a space in back that could easily accommodate a queen instead), toilet and shower stall, full kitchen with a 6' long counter on one side, fold-up kitchen table, fold up 53" long desk and a near full-length couch with storage ottomans.
The wheel wells are really not a problem at all with this layout. The large kitchen sink is over one of them and the long countertop/cabinet is over the other, so all they really cost me is some storage space.