If long distance travel is the only issue here, perhaps you should consider an SUV. My wife has similar issues due to an auto accident resulting in a spinal fusion. We have an SUV for her, and when we travel long distance she rests on a mattress in the back that I had made for it. We have a Durango with a split bench middle seat, so if she wants to sit she can sit in the seat not taken by the mattress. And, it folds up so if we want to use all the other seats for passengers, they are available and the mattress rides in the very back. An SUV might suit your needs without the expense and hassle of a bus conversion. The only drawback is when she's laying down we only have 2 available seats, or a very small area for luggage. We used to have a Tahoe that had more room when she was laying down, but the ride was a lot worse.
Anyway, this is something you can test by renting an SUV then traveling somewhere to see if it will work. You can make a temp mattress out of some blankets, and if it works look for a custom mattress shop that can make a mattress to fit. I can send you the name of our mattress guy if you need it. He's out of Oklahoma, but can make a custom sized mattress from memory foam and latex foam that folds in the middle for easy storage.
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