I have a 40A Renogy DC-DC charger...I'm a little confused about your terminology - when you refer to the "12v supply line" do you mean the positive input to the charger? (On my parts diagram, this is listed as Key Part #2.)
Regarding the 12v switched line, I believe this is labeled "D+" - correct?
Assuming the above is the case, I am not sure why you would not just control the on-off function by putting a switch in the feed line to the D+ line (rather than tying it into the headlights), and having the positive input always supplying the charger. The charger is set up such that it will not pass power through to the house batteries unless it is 'turned on' by supplying power to the D+ terminal.
My charger is wired this way, where I used an extra switch in the driver's control panel to supply the 12v signal to the D+ terminal. The 12v input and output lines (from the alternator / to the house batteries) have inline isolation breakers, but these are more for overcurrent protection, and not used to switch power on/off.
Post #15 of my build thread (
https://www.skoolie.net/forums/f11/t...nic-42584.html) shows a pic of the switch panel, and post #40 is a description of the electrical system. I would tend to avoid having the high amperage line as the one that you use to control power to the charger - if that's in fact what you were asking about.