you certainly can replace it.. my suggestion would be to install a bulkhead evaporator up-front in the front bulkhead. if you are insulating your bus well you may very well be able to delete the rear system altogether if your bus has 2 and the passengers plan to ride up front during road trips.
here is an example of one. don brown isnt likely the best place. shop around for a used one or better pricing but id expect to pay a grand or so for one.
https://donbrownbusparts.com/product...002-1001325385
these are typically sized very similar to a Carrier EM-1 or a Trans/ AIR 4-vent dual blower system.
not knowing what your current evaporator and condenser model numbers are makes it a bit tougher for me to help you out..