Sweeeeet! That little Isuzu should easily be good to a half a million. I believe they are rated about the same as the Cummins B series. And, as long as you are getting "fancy" with that darlin, have you taken a look at the Allison, 4th gen 6-speed trannies? They are double OD units that are extremely well built and could probably squeeze another 20% in mileage out of that motor. And while the 4th generations ('97 & up) are computer controlled, they are fairly easily mated to non-computer engines (like mine...not sure what the electronics on the 5.2 are). Either way, they are stout, smooth & economical. I have just started building one to go behind my 4BTAA (only 130hp & 355 toque). The 2200 series HS can easily handle the Isuzu. If you are interested, here are a few of the numbers for the 2200HS close ratio...
HP - 340
Torque - 575
GVW - 26,000
Gearing:
1 - 3.10:1
2 - 1.81:1
3 - 1.41:1
4 - 1:1
5 - .071:1
6 - .061:1
Might be fun to run the numbers through a gear/tire calc to see where your rpm's would be at hiway speed. BTW...this tranny can be had as a full-locker with a parking pawl. Handy on down hills for braking and parking.
Anyhow, just thought I'd pass that along. Keep up the good work & pictures!