Thank you for the response and the great articles you PM'd me.
I am just looking for ballpark weights and understand the huge number of variables that affect everyone's numbers.
The engine in the bus is a 6.0l 366 gasser with a 4sp automatic transmission.
Is it possible to have the rear wheels upgraded?
I think it might be easier to swap axles (front and rear) if it is split rim. However, that's not totally a bad thing if it's hydraulic brake, can give you the opportunity to upgrade to air brakes, though both are a bit involved to do. Would also give the opportunity to upgrade to a rear axle gear ratio more suitable to your intended driving.
The wheels I speak of that are dangerous to mount are referred to as Dayton wheels. The safer, more modern design are known as Budd wheels. They have two to five handholds and are a solid one-piece design (essentially two pieces welded together, but essentially one piece, as opposed to the Daytons).
The 366 is an excellent engine, but keep it below 4000 rpm, it isn't designed to spin any faster. My guess would be you would probably be looking at about a 12,000-lb empty weight before build-out and about 55-60 mph top speed cruising...
The 4-speed auto you mention is likely an AT545, not the best one out there, unfortunately. It's okay if you're not doing a lot of highway cruising or mountain driving, but it's the basic offering and fairly weak compared to the MT643, its beefier sibling...
Here is a way to tell the difference... The MT643's fluid pan has a temperature sensor, usually on the driver's side of the pan. The AT545 does not. The MT643 also has a different trans mount pattern than the AT545... Here is a quick ID guide to Allison automatics...

I don't mention these things so much as a 'walk-away' if the bus will still serve your purposes (a tiny home that spends 98% of its time parked doesn't have as much cause for concern for these sorts of things), but more of a consideration for bargaining power on price should you find it will serve your purposes.