Our skoolie is to become a ten bedded bunkhouse, because hotels aren't an option for a family this size.
In a couple weeks our fifth will come along and we'll be 7 in all. I already feel like hotels aren't an option! (and airfare isn't either!)
I haven't put up a decent floor plan for my build yet but I'll describe it briefly. We'll build a room just big enough for a queen bed over the rear engine for the two of us. On each side of the bus, above the rear wheel wells, will be a stack of three bunk beds (one more bed than kids in case a friend comes along, and for symmetry). We're doing a roof raise in part so that these bunks can each have about 22" of vertical space with a 5" allowance for the thickness of each bunk. The middle bunk will have a 4-bar linkage so it can pivot downward and, together with the lower bunk, form a bench/couch for daytime use.
Early in the design we'd thought about doing bunks over the engine also (two, or maybe three) for a total of 8 or 9 beds in back. We would have designed the front area to be benches while driving and convertible to a queen or king bed when parked, but I scratched that idea because I don't want to drive until drowsiness is near, then have to spend half an hour putting the bed together before I can sleep. So the over-engine bunks got dumped in favor of a queen bed instead.
As nat_ster said, insulation is the most critical thing for cooling. The money will be spent either way -- on a huge A/C system, or on insulation. I haven't worked out the "on the move" part of the equation for mine yet. Engine-driven would be nice, but I want to use the A/C while the engine is off too (and not have dual systems), and it seems complicated to design a single system with two parallel compressors, or a compressor clutched for two power sources, etc. Depending on the size of the A/C it might be possible to run from an inverter off a battery bank and use the engine alternator to recharge at the same time. The load on the alternator would be reduced according to the compressor's duty cycle -- but if the duty cycle is high then this scheme doesn't help reduce average alternator load. Probably I'll end up with a generator powering our A/C.
Also get rid of as many windows as you can; windows bring an incredible amount of heat in when the sun shines.
Oh.. paint it white, too. Somewhere 'round here there's a thread that concludes the mystical insulating beads are ineffective; just go with a nice white elastomeric roof paint.