Cruising at 70 mph at such low RPM's is assuming an awful lot....like that your DT466 will be able to push you at such low RPM's and that it won't take a day to get there. Sure Class 8 trucks run lower rpm's than that for those cruise speeds, but they have TREMENDOUS amounts of torque right off idle and some nifty computers in the new trucks that keep everything running as best as it can in the given conditions.
The DT466 is no slug...it is probably the undisputed champion in a quasi-modern school bus in terms of powerplants, but it still can't work miracles. The same gearing that limits your top end also allows you to accelerate faster. I have a feeling your MT643 won't last long with you lugging the engine that low simply because there won't be enough torque available to keep that torque converter locked up. With a lockup torque converter, you've just made it a wear part because of the clutch. I don't claim to be a mechanic, but I'd seen plenty of people toast transmissions in 4wd rigs by trying to turn 38.5 inch tall tires with stock gears. Sure it looks good on paper, but in practice it just won't work and throwing more power at the problem often only makes things worse.
Long story short....before you start throwing lots of money at a set of 3.08 gears, I'd think long and hard about it. Chances are gears that high were never offered in that chassis for a reason.