May we assume this is a full-sized bus on a commercial truck chassis? If you mean differences between aluminum wheels and your bus' OEM steel wheels? Yes. Nothing major, just critical. I assume that you will be taking your bus to an experience big truck/commercial vehicle tire shop for the change over. If so, they can help you out with what you'll need to make the switch to aluminum wheels.
In a nutshell, because the aluminum wheels are thicker material and more ductile, they will require (by DOT, too) different lug nuts. You *might* also require longer wheel studs, too. Maybe not -- again, your tire shop will guide you here. So do not be alarmed or think that its just a scam to charge you more -- new nuts and possibly new studs will be a requirement. There might be other issues I'm not aware of, but in the practical real world, the studs and lug nuts are all you really need to worry about and a good tire shop can deal with that for you. Its not terribly difficult or complicated, but not something you should do on your own if you aren't trained and experienced in this.
And just beware -- those shiny Alcoas will sure look pretty ... but they will take some continuous work to stay that way

I've spent a lot of time cleaning, polishing and cleaning and polishing aluminum wheels on the various 18-wheelers I've driven. I'm keeping the steel (painted) wheels on my bus

Class 7 and 8 vehicles produce a LOT of brake dust. Brake dust and aluminum wheels do not get along.
And if your bus is unmolested/unmodified, the wheels should fit front to back. Just remember "Steers" and "Drives" refer to the position of the tire on the vehicle and the tread design. Unless you will be traveling exclusively on nice asphalt or concrete highways, its generally inadviseable to put a steer tire in a drive position (traction issues). Likewise, unless you have a 4x4 or 6x6 (etc) vehicle, its a waste of money to put drivers on the front.
As to why your friend couldn't switch wheels front to back, there could be many reasons -- and none of them good in my mind. The lug pattern for all the class 7 and 8 vehicles I've ever driven (with Budd style wheels) is pretty much the same/standard pattern. Wheels should be able to switch to any position on your bus.
Again, this is for your info. Let a tire professional handle the switch to aluminum wheels for you.
Regards!
John