This begs the question "what is unnecessary?" and that depends partly on your intended use. Planning to continue hauling passengers, many of the safety systems will need to be left intact and functional. I'm making an assumption that you'll be doing a conversion into living space, so the door/window/emergency exit safety switches can be deleted. However, I would not necessarily remove the wires because they can be repurposed for other uses such as extra interior lighting, radio speakers, camera(s), etc. It's far easier to use an existing wire than to run a new one (and cheaper too).
All that said, I would only disconnect one or two wires at a time, and make sure the bus still starts (it would be pretty easy to reconnect the 2 and restore functionality, not so much after you've removed a dozen and have no idea what went where). Some interlock systems require a full circuit to be complete, others require the circuit to be "open". In the first case, it can easily by bypassed with a short section of wire, for the second, it won't care what was disconnected (It looks for anything "closed", completing the circuit).